Our December issue review highlights includes:
· Protein–ligand structures in drug discovery
· Biosimilars and biobetters: immunogenicity of biotherapeutics
· Structural mass spectrometry in biologics discovery
· Applications of Connectivity Map
Cover Story
The leading story of this issue of Drug Discovery Today reflects on the methods for assessing protein–ligand structure quality and a new set of identification criteria are presented. Protein–ligand structures are the core data required for structure-based drug design (SBDD). Understanding the error present in this data is essential to the successful development of SBDD tools. This review discusses methods for assessing the quality of this critical data.
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