Our February issue review highlights includes:
· Mechanistic systems modeling to guide drug discovery
· A chemistry wiki to facilitate and enhance compound design
· Emergence of zebrafish models in oncology
· Low-dose metronomic chemotherapy
Cover Story
The leading story of this issue of Drug Discovery Today focuses on large mechanistic models of biological systems, especially those with applications in drug development. They explain that such approaches have demonstrated value to industrial research programs, and they posit that they will become an integral component of research practice as the pharmaceutical industry transitions to increasing utilization of computational approaches as a component of an evolving research paradigm.
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