Clinical and biological data integration for biomarker discovery

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Sorani et al. describe a data integration strategy that implements a clinical and biological database and a wiki interface. They integrated parameters across clinical trials and associated genetic, gene expression and protein data. They also provide examples to illustrate the utility of data integration to explore disease heterogeneity and develop predictive biomarkers.

In this article the author discuss strategies to standardize data across clinical trials, to integrate clinical and biological data and to make data and supporting information broadly accessible. They describe, in detail, efforts at their institution to implement an integrated database system for the discovery of biomarkers in autoimmune disease, including examples of analyses performed using the system.

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