Features for August 2009

Features Archive

Drug Discovery Today: highlighted review. ‘Metabolite-likeness’ as a criterion in the design and selection of pharmaceutical drug libraries

This highlighted review from Drug Discovery Today by Dobson, Patel and Kell outlines how "metabolite-likeness" in an analogous manner to "drug-likeness" and "lead-likeness" can be used to improve the value of compound libraries design by incorporating features of endogenous metabolites ("endogenites")

Drug Discovery Today Citation Classic: The growing impact of click chemistry on drug discovery.

Welcome to the first article in Drug Discovery Today Citation Classics. I would say that it is very hard to predict what articles will make citation classic articles, but I suppose that having a Nobel Prize-winning author and a topic of great significance to the field of synthetic medicinal chemistry is a pretty good start.

Most downloaded review Q1 2009: Target discovery from data mining approaches

The most downloaded review article from Drug Discovery Today from the first quarter of 2009 deals with the topic of target discovery from the informatics perspective. It would be difficult to overstate the value to Pharma of identifying and validating the most relevant therapeutic targets. In this article, Yang, Adelstein and Kassis outline text mining, its value and limitations and application to target discovery. In addition, they cover the field of emerging and integrated data mining approaches.