Features for January 2012

Features Archive

Drug discovery in the next decade:innovation needed ASAP Drug discovery in the next decade:innovation needed ASAP

The pharmaceutical sector, a cornerstone of the healthcare industry, is undergoing dramaticchange, primarily caused by reduced output of new medicines from research and development(R&D) laboratories, drug pricing pressures, stricter regulatory environments and the overallcurrent economic downturn. This makes demands of all pharmaceutical companies to find better ways to increase their output of new drugs, through innovation, to both treat patients and meet their shareholders’ expectations.

Learning lessons from drugs that haverecently entered the market Learning lessons from drugs that haverecently entered the market

In this article, the most downloaded of Q2 2011, Simon Teague outlines that the key determinants for success in drug discovery can be defined by studying recently launched drugs.

The graphical representation of ADME-related molecule properties for medicinal chemists The graphical representation of ADME-related molecule properties for medicinal chemists

In this article, the most downloaded of Q1 2011, Timothy J. Ritchie, Peter Ertl and Richard Lewis review various approaches that have been used to represent molecule properties graphically in the context of oral ‘drug likeness’, with the goal of improving the decision making of medicinal chemists during the drug discovery process.