Medicinal Chemistry Features for February 2011

Medicinal Chemistry Features Archive

Pharmacophore modeling and applications in drug discovery: challenges and recent advances Pharmacophore modeling and applications in drug discovery: challenges and recent advances

The most downloaded article from Drug Discovery Today in Q2 2010 was by Sheng-Yong Yang and deals with the application of pharmacophore modeling to drug discovery.

Visualizing the drug target landscape Visualizing the drug target landscape

This article, by Stephen J. Campbell, Anna Gaulton, Jason Marshall, Dmitri Bichko, Sid Martin, Cory Brouwer1 and Lee Harland was the most downloaded article of Q1 2010. It deals with tools to integrate biological, chemical and clinical resources.

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design? The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

The content of the most downloaded article in Q4 2009 deals with the impact of the number of aromatic rings on the ability to deliver quality compounds for drug development. This information and analysis is clearly highly important and directly relevant to the day-to-day work of the medicinal chemist.

Transforming fragments into candidates: small becomes big in medicinal chemistry Transforming fragments into candidates: small becomes big in medicinal chemistry

Again, medicinal chemistry features highly in our "Most downloaded" spot. This time we feature the extremely hot topic of fragment-based drug discovery, from some of the most influential experts, based in the Netherlands and the UK

Medicinal chemistry strategies in follow-on drug discovery

This article was the most downloaded article in the period Q2 2009. A common theme appears with many of our most popular articles in that they frequently relate to medicinal chemistry strategy or practice. I hope that you enjoy this article.