Pharmacology/ Therapeutics News for September 2012

Pharmacology/ Therapeutics News Archive

New way of fighting high cholesterol upends assumptions New way of fighting high cholesterol upends assumptions

Atherosclerosis – the hardening of arteries that is a primary cause of cardiovascular disease and death – has long been presumed to be the fateful consequence of complicated interactions between overabundant cholesterol and resulting inflammation in the heart and blood vessels. However, researchers at the University of California, San Diego School of Medicine, with colleagues at institutions across the country, say the relationship is not exactly what it appears, and that a precursor to cholesterol actually suppresses inflammatory response genes. This precursor molecule could provide a new target for drugs designed to treat atherosclerosis, which kills tens of thousands of Americans annually.

Discovery of reprogramming signature may help overcome barriers to stem cell-based regenerative medicine Discovery of reprogramming signature may help overcome barriers to stem cell-based regenerative medicine

Salk scientists have identified a unique molecular signature in induced pluripotent stem cells (iPSCs), "reprogrammed" cells that show great promise in regenerative medicine thanks to their ability to generate a range of body tissues

Drug combination against NRAS-mutant melanoma discovered Drug combination against NRAS-mutant melanoma discovered

A new study published online in Nature Medicine, led by scientists at The University of Texas MD Anderson Cancer Center, describes the discovery of a novel drug combination aimed at a subset of melanoma patients who currently have no effective therapeutic options.

Human stem cells restore hearing Human stem cells restore hearing

A cure for deafness is a step closer after University of Sheffield scientists used human embryonic stem cells to restore hearing in a common form of deafness.

Strategy developed to improve delivery of medicines to the brain Strategy developed to improve delivery of medicines to the brain

New research offers a possible strategy for treating central nervous system diseases, such as brain and spinal cord injury, brain cancer, epilepsy, and neurological complications of HIV.

Harnessing anticancer drugs for the future fight against influenza Harnessing anticancer drugs for the future fight against influenza

Medical Systems Virology group at the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki, together with its national and international collaborators, developed a new cell screening method that can be used to identify potential anti-influenza drugs.

New study shows promise in using RNA nanotechnology to treat cancers and viral infections New study shows promise in using RNA nanotechnology to treat cancers and viral infections

A new study by University of Kentucky researchers shows promise for developing ultrastable RNA nanoparticles that may help treat cancer and viral infections by regulating cell function and binding to cancers without harming surrounding tissue.

Can't smell anything? This discovery may give you hope Can't smell anything? This discovery may give you hope

Scientists have restored the sense of smell in mice through gene therapy for the first time -- a hopeful sign for people who can't smell anything from birth or lose it due to disease.